Literature databases are goldmines of information, and Medavise team are experts at finding the hidden nuggets. Understanding a medical treatment state of the art is critical for FDA submissions as well as for EU Clinical Evaluation Reports and Post-Market Surveillance. Medavise uses a standardized overall approach based on the Cochrane Collaboration and the PICO strategy to develop the Research Question. We commonly use the PubMed, EMBASE and Europe PMC databases as well searches of clinical trials registries and other sources of grey literature as needed. Filtering of results is performed using the PRISMA concept. For CERs, the included literature is appraised using a unique method that specifically addresses the MDR and related guidance requirements.